Methods: This was a randomized, double-blind, placebo-controlled trial of sucralfate versus placebo conducted between and in an urban pediatric emergency department. The primary outcome was oral fluid intake within 60 minutes of medication administration.
The secondary outcomes were repeat ED visits, length of stay in ED, intravenous hydration rate, admission rate, adverse event rate, and emergency physician's determination of the adequacy of oral intake. Results: One hundred subjects with mild dehydration clinical dehydration score of 1 and a median age of 1. Oral intake 1 hour after drug administration was similar in both the groups: the median intake in the sucralfate group was 9.
Conclusion: Sucralfate as an adjunct to oral analgesics was not superior to placebo in improving oral intake in children with acute oral infectious ulcers. Study hypothesis: We hypothesized that sucralfate along with oral analgesics acetaminophen or ibuprofen administered in the emergency department leads to a clinically significant improvement in oral intake in children with acute infectious oral ulcers.
Methods: This was a randomized, double-blind, placebo-controlled trial of sucralfate versus placebo conducted between and in an urban pediatric emergency department. The primary outcome was oral fluid intake within 60 minutes of medication administration. The secondary outcomes were repeat ED visits, length of stay in ED, intravenous hydration rate, admission rate, adverse event rate, and emergency physician's determination of the adequacy of oral intake. Results: One hundred subjects with mild dehydration clinical dehydration score of 1 and a median age of 1.
Oral intake 1 hour after drug administration was similar in both the groups: the median intake in the sucralfate group was 9.
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